Dr Paul L Durham, PhD . Distinguished Professor of Cell Biology
Understanding The Epigenome: A Pathway to Personalized Medicine
Friday June 8th 2018 in York
Fee:£108 for members and £216 non members
Dr. Paul Durham is Distinguished Professor of Cell Biology at Missouri State University and Director of its Center for Biomedical and Life Sciences, a multidisciplinary laboratory that utilizes cellular/molecular, microbiological, biochemical and chemical techniques.
He has a special interest in temporomandibular dysfunction and migraine.
Epigenetics is the study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself.
That means we can actively influence the genetic hand we were all dealt.
Paul will talk about how the way we live impact our health and potentially the health of our children 2 generations down the line, how pain in one area of our bodies sets us up to be more likely to get further problems, why treating TMD can aid migraine sufferers and why chicken soup is indeed good for our health.
He describes the pain fatigue cycle and how stress, muscle tension, poor sleep, depression and emotions can cause us/our patients to be caught up in this.
He illuminates areas as wide as genomes, nicotine, vaginal births, antibiotics and gut bacteria
A primary goal of his research is to determine the signaling pathways by which inflammatory and anti-inflammatory agents control neuropeptide gene expression in disorders involving the trigeminal nerve. Currently, he is studying the regulation of protein expression in cultured nerve and glial cells, human cell lines, in vivo animal models and clinical studies. A major focus of his research has been to elucidate the cellular/molecular mechanisms by which novel drugs and nutraceuticals modulate the excitability state of neurons and glial cells under pathological conditions in models of migraine, TMJ disorder and epilepsy. More recently, his laboratory has been investigating epigenetic mechanisms and changes in gut microbiota in response to changes in diet, sleep pattern, stress and chronic inflammation.
Dr. Durham is frequently invited as a guest lecturer. He has published more than 70 peer-reviewed research articles and more than 100 abstracts. He is a member of the Society for Neuroscience, the American Association for the Advancement of Science, the American Headache Society, the American Pain Society and the American Academy of Orofacial Pain. In addition, he has served on numerous study sections for the National Institutes of Health, as well as pharmaceutical company advisory boards, and is currently a reviewer for more than 10 journals.
A major focus of his research has been to elucidate the cellular/molecular mechanisms by which novel drugs and nutraceuticals modulate the excitability state of neurons and glial cells under pathological conditions. More recently, his laboratory has been investigating epigenetic changes in response to changes in diet, sleep pattern, and chronic inflammation. A frequently invited guest lecturer and the author of >75 peer-reviewed research articles and >150 published abstracts. Dr. Durham has served on numerous NIH study sections and pharmaceutical company advisory boards and is currently a reviewer for more than 10 scientific journals. Dr. Durham is a member of the Society for Neuroscience, American Headache Society, American Pain Society, and American Academy of Orofacial Pain.
Summary of program and course objectives
We are now coming to appreciate the notion that both nature (genetics) and nurture (epigenetics) play key roles in disease progression and the development of chronic pain states. Recent advances in the fields of genomics and bioinformatics are providing strong evidence of the fact that changes in our genetic code (mutations) alone cannot explain how the genome regulates the development and function of complex multicellular organisms. Rather, epigenetic changes that involve controlling how our DNA is packaged and, thus determining which genes are turned on or off, allows for adaptive evolution and a new way to view human health and disease. Hence, while we might have a genetic predisposition towards a particular disease, our life style choices involving diet, sleep, exercise, and our environment play an important role in maintaining and restoring a healthy physiology.
The goal of this course is to provide a comprehensive view of how lifestyle choices and environment impact disease progression and our overall well-being, and present strategies to help your patients maintain a healthy epigenome.
1. Know the difference between one’s genome and epigenome and the relevance to understanding human health and disease progression.
2. Appreciate the dynamic nature of our epigenome which allows for adaptive evolution and the ability to prevent expression of genes that predispose one to a particular disease.
3. Understand the importance of a patient’s environment (stress), and life style choices such as sleep, exercise, and diet in the development of chronic orofacial pain conditions.
4. Gain new insights into the pathology of orofacial pain conditions and new treatment strategies to help modulate sensitization of the trigeminal system and minimize risk factors.
Anyone interested in understanding the pathology of orofacial pain conditions and learning how to better manage a chronic pain patient by changing their epigenome through life style and dietary changes. Dentists, physicians, nurses, physical therapists, or other orofacial pain specialists.
9 am – Epigenetic Basics – History, Mechanisms, Role in Human Disease
10:30 Epigenetics and Chronic Pain
11:45 Morning Discussion – Q&A
1:00 Epigenetics, Neurological Diseases, and Stress
2:15 Epigenetics, Sleep, and Exercise
3:30 Epigenetics, Nutrition, and Gut-Brain Axis
4:30 Wrap up and general discussion of key clinical pearls
5:00 End of Day
Links to our research:
1. https://jvic.missouristate.edu/cbls/ –Paul Durham lab’s home page
2. Profile on Research Gate: https://www.researchgate.net/profile/Paul_Durham
3. https://blogs.missouristate.edu/mindseye/2013/08/ — feature on research
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Fee:£108 for members and £216 non members
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